Radiation Oncology Chulolongkorn University

à¤ÁպӺѴ (Chemotherapy)

µéͧÃÐÅÖ¡äÇéàÊÁÍÇèÒ¡ÒÃÃÑ¡ÉÒËÅÑ¡¢Í§ÁÐàÃ移ҡÁ´ÅÙ¡¤×Í ¡ÒüèҵѴ áÅÐ/ËÃ×Í ¡ÒéÒÂÃѧÊÕ
ÂÒà¤ÁպӺѴ¹Ñé¹äÁèÊÒÁÒö¹ÓÁÒãªéá·¹¡ÒÃÃÑ¡ÉÒ´éÇ¡ÒüèҵѴËÃ×Í©ÒÂÃѧÊÕ áµèÂÒà¤ÁպӺѴÍÒ¨¹ÓÁÒãªé
ä´é㹡óշÕèÁÕ¡ÒáÅѺà»ç¹«éӢͧâä ËÃ×ÍÁÕ¡ÒÃá¾Ãè¡ÃШÒ¢ͧâä áÅÐ㹺ҧ¤ÃÑé§ÍÒ¨¹ÓÁÒãªéÃèÇÁ¡Ñº
¡ÒéÒÂÃѧÊÕ à¾×èÍËÇѧ¼Å㹡ÒäǺ¤ØÁâä੾ÒзÕèãËé´Õ¢Öé¹ ·ÓãËéÁÕÃÐÂÐàÇÅÒ»ÅÍ´âä (disease-free
survival) áÅÐÍÒ¨·ÓãËéÁÕÍѵÃÒ¡ÒÃÃÍ´ªÕÇÔµ (overall survival) à¾ÔèÁÁÒ¡¢Öé¹ 44-49
»Ñ¨¨ØºÑ¹¹ÕéÁÕ¡ÒÃÈÖ¡ÉÒÇԨѡÒÃãªéÂÒà¤ÁպӺѴ㹡ÒÃÃÑ¡ÉÒÁÐàÃ移ҡÁ´ÅÙ¡ÍÂèÒ§¡ÇéÒ§¢ÇÒ§
â´Â੾ÒÐã¹¼Ùé»èÇÂÁÐàÃ移ҡÁ´ÅÙ¡·ÕèÁÕ¡ÒáÅѺà»ç¹ãËÁè¢Í§âäÀÒÂËÅѧ¡ÒÃÃÑ¡ÉÒ´éÇÂÃѧÊÕ ËÃ×Í
¡ÒüèҵѴ áÅмÙé»èÇ·ÕèÁÕ¡ÒÃá¾Ãè¡ÃШÒ¢ͧâää»ÂѧÍÇÑÂÇеèÒ§ æ
Cisplatin ¨Ñ´ÇèÒà»ç¹ÂÒ«Öè§ÍÍ¡Ä·¸Ôìä´é»ÃÐÊÔ·¸ÔÀÒ¾ÊÙ§Êش㹡ÒÃÃÑ¡ÉÒÁÐàÃ移ҡÁ´ÅÙ¡
¢¹Ò´¢Í§ÂÒ·Õèãªé 50-100 mg/m2 ãËé·Ø¡ 3-4 ÊÑ»´ÒËì ¾ºÇèÒÁÕ¡Òõͺʹͧ (overall response rate)
»ÃÐÁÒ³ 30-40%
¹Í¡¨Ò¡¹Õé¡çÂѧÁÕÂÒà¤ÁպӺѴµÑÇÍ×è¹ æ ÍÕ¡ àªè¹ Bleomycin, Doxorubicin, Mitomycin-C,
Methotrexate, Ifosfamide, 5-Fluouracil à»ç¹µé¹ «Ö觨ÐÁÕ¡ÒõͺʹͧÍÂÙèÃÐËÇèÒ§ 10-25% ´Ñ§áÊ´§
ã¹µÒÃÒ§·Õè 5

µÒÃÒ§·Õè 5 Single agent activity against squamous cell carcinoma of cervix 50-52

Êèǹ¡ÒÃãªéÂÒà¤ÁպӺѴµÑé§áµè 2 µÑÇ¢Öé¹ä» (combination chemotherapy) ¾ºÇèÒÁÕ¡Òõͺʹͧ
µèÍ¡ÒÃÃÑ¡ÉÒ·Õè´Õ¢Öé¹ ÍÂèÒ§äáçµÒÁ¼Å¢éÒ§à¤Õ§áÅÐÀÒÇÐá·Ã¡«é͹·Õèà¡Ô´¢Ö鹨ҡ¡ÒÃÃÑ¡ÉÒ¡çÊÙ§ÁÒ¡¢Öé¹
àªè¹¡Ñ¹ Combination Chemotherapy ·Õèä´é¼Å´Õ àªè¹
- Bleomycin + Mitomycin-C 53
- Bleomycin + Methotrexate 54
- Cyclophosphamide + Adriamycin + Cisplatinum (CAP) 55
- Cisplatinum + Vinblastine + Bleomycin (PVB) 56
- Bleomycin + Methotrexate + Cisplatinum (BMP)57
â´Â¨Ð¾ºÇèÒÁÕ¡ÒõͺʹͧµèÍ¡ÒÃÃÑ¡ÉÒÍÂÙèÃÐËÇèÒ§ 55% - 93% áÅÐÁÕªèǧàÇÅÒ¡Òõͺʹͧ
(Duration of response) 3 - 30 à´×͹

Last modified on 25 October 1996