Radiation Oncology Chulolongkorn University

Moderate Dose Preoperative Irradiation

¤×Í¡ÒéÒÂÃѧÊÕã¹¢¹Ò´µÑé§áµè 3,000-4,000 cGy ¡è͹¡Ò÷ӼèҵѴ ÁÕ¡ÒÃÈÖ¡ÉÒà»ÃÕºà·Õº
(randomized trial) ÍÂÙèËÅÒÂʶҺѹ ¼Å¡ÒÃÈÖ¡ÉÒ·Õèä´é·ÓãËéàª×èÍÇèÒÁÕ»ÃÐâª¹ì ¤×Í ¡ÒÃãªé moderate dose
preoperative irradiation ¹Ñé¹ ÊÒÁÒö·Õè¨ÐÅ´¡ÒáÓàÃÔº¢Í§âä੾ÒзÕèãËéà¡Ô´¹éÍÂŧàÁ×èÍà»ÃÕºà·Õº¡Ñº¡Ò÷ӼèҵѴÍÂèÒ§à´ÕÂÇ áµèä´é¼Å·ÕèäÁè¤èÍÂá¨èÁªÑ´¹Ñ¡ã¹·Ò§´éÒ¹¢Í§¡ÒÃÅ´ÍѵÃÒ¡ÒáÓàÃÔº¢Í§âä¹Í¡ÍØé§àªÔ§¡ÃÒ¹ áÅÐÍѵÃÒ¡ÒÃÃÍ´ªÕÇÔµ (extrapelvic recurrence áÅÐ over all survival) àªè¹ ÃÒ§ҹ¡ÒÈÖ¡É
¢Í§ European Organization for Research and Treatment of Cancer study7 (EORTC) ä´éáºè§¼Ùé»èÇÂ
à»ç¹¡ÅØèÁ·ÕèãËé¡ÒÃÃÑ¡ÉÒâ´Â¡Ò÷ӼèҵѴÍÂèÒ§à´ÕÂÇ à»ÃÕºà·Õº¡Ñº¡ÅØèÁ·ÕèãËé preoperative irradiation
´éÇ»ÃÔÁÒ³ÃѧÊÕ 3,450 cGy, 230 cGy/fraction áÅéǵÒÁ´éÇ¡Ò÷ӼèҵѴ ¾ºÇèÒ㹡ÅØèÁ·Õèä´é preoperative irradiation ÁÕ¡ÒáÓàÃÔº¢Í§âä੾ÒзÕè¹éÍ¡ÇèÒ¡ÅØèÁ·Õè·Ó¼èҵѴÍÂèÒ§à´ÕÂÇ ¤×Í 15% áÅÐ 30% (P=0.003)
ã¹¢³Ð·ÕèÍѵÃÒ¡ÒÃÃÍ´ªÕÇÔµ·Õè 5 »ÕäÁèᵡµèÒ§¡Ñ¹¤×Í 69.0% áÅÐ 59.1% (p=0.08) µÒÁÅӴѺ ¹Í¡¨Ò¡¹Õé
¡çÁÕÃÒ§ҹ¢Í§ Reis Neto et al8 ¨Ò¡ Sao Paulo »ÃÐà·ÈºÃÒ«ÔÅ ÇèÒ¡ÒÃãªé preoperative irradiation â´Âãªé»ÃÔÁÒ³ÃѧÊÕ¢¹Ò´ 4,000 cGy, 200 cGy/fraction ¨ÐÊÒÁÒöŴÍغѵԡÒáÓàÃÔº¢Í§âä੾ÒзÕèŧ áÅÐÂѧÊÒÁÒöà¾ÔèÁÍѵÃÒ¡ÒÃÃÍ´ªÕÇÔµ¢Í§¼Ùé»èÇÂä´é àÁ×èÍà·Õº¡Ñº¡ÅØèÁ·Õè·Ó¼èҵѴÍÂèÒ§à´ÕÂÇ áµè¡çÁÕÃÒ§ҹ¨Ò¡ºÒ§Ê¶ÒºÑ¹¼Å¡ÒÃÈÖ¡ÉÒ·Õèä´éäÁèʹѺʹعÇèÒ¡ÒÃãªé moderate dose preoperative irradiation ä´é»ÃÐ⪹ì àªè¹ randomized trial ¨Ò¡¡ÒÃÈÖ¡ÉҢͧ Veterans Administration Surgical Adjuvant
Group9 (VASAG II) ã¹»Õ 1986 ¾ºÇèÒ¡ÒéÒÂÃѧÊÕ preoperative irradiation ¢¹Ò´ 3,150 cGy, 175 cGy
/fraction ÁÕ¡ÒáÓàÃÔº¢Í§âä੾ÒзÕèáÅÐÍѵÃÒ¡ÒÃÃÍ´ªÕÇÔµ¢Í§¼Ùé»èÇ à·èҡѹ¡Ñº¡Ò÷ӼèҵѴÍÂèÒ§à´ÕÂÇ
¤×ÍÁÕÍѵÃÒ¡ÒÃÃÍ´ªÕÇÔµ·Õè 5 »Õ à·èҡѺ 50% ·Ñé§ 2 ¡ÅØèÁ µÒÃÒ§·Õè 4 áÊ´§¼Å¢Í§¡ÒÃãªé moderate dose preoperative radiation

µÒÃÒ§·Õè 4 Randomized Trials of Moderate Dose Preoperative Radiotherapy

Last modified on 25 October 1996